Nicotinamide adenine dinucleotide (NAD) is a naturally occurring molecule that exists in every cell of our bodies. NAD plays a vital role in maintaining healthy brain function, regulation of the nervous system, metabolism, and the body's ability to repair damage. As we age, NAD+ levels naturally decline, and this may play a role in the increased risk for chronic diseases.                                                                                      

 

Importance of NAD+ In the Human Body 
1) Genomic Stability  
cellular DNA damage occurs due to either endogenous or exogenous factors, genomic instability occurs, which may result in cancer development and an increased rate of cellular aging.  there is a process in the body known as DNA-damage response (DDR). DDR is a process that detects and repairs any damaged DNA in the body. DDR is a process that is highly dependent on NAD+; when amounts of NAD+ are low in the body, the DDR process is impaired, resulting in increased damage to the cellular DNA.                            2) Genetic Expression 
Histone modification is a NAD+ dependent process; a deficiency in NAD+ levels may disrupt histone modification, which may impair genetic expression. NAD+ deficiency may also result in the methylation of cellular DNA so that genes are not expressed appropriately                                                                                  3) Immunity and Inflammation
NAD+ levels in the human body determine the extent as well as the effectiveness of immune responses during infection. Increased levels of NAD+ during an infection increase oxidative phosphorylation in macrophages, which makes them better able to neutralize the organism causing the infection.                    4) Energy Metabolism  
All the energy metabolic pathways require the presence of NAD+ as a coenzyme to function properly. A deficiency of NAD+ in the body may impact all these processes and negatively impact the effectiveness by which energy is generated and utilized by the body.                                                                                              5) Circadian Clock  
The circadian clock, also known as the biological clock or circadian rhythm, is an internal endogenous process that regulates the sleep-wake cycle in the human body. This internal clock helps the body adjust to different times of the day or the different seasons. The accuracy and effectiveness of the circadian clock are due in part to cellular levels of NAD+. A deficiency of NAD+ may disrupt the circadian rhythm and result in effects such as daytime sleepiness, restless sleep, hormonal imbalances, and mood alterations, among others.

6) Cardiovascular Function  
The heart is the most metabolically active organ in the human body because it is constantly beating. Studies have shown that normal NAD+ levels are essential in maintaining the metabolic activity of the heart. Furthermore, in the event of a significant cardiac event such as a transient ischemic attack or myocardial infarction, normal levels of NAD+ help in the recovery from injury.

7) Kidney Function  
Generally, renal function has a tendency to decrease as people get older. It is suspected that reduced levels of NAD+ in the elderly may have a role to play in the reduction in renal function. Research has indicated increased protection against acute renal injury when individuals were given NAD+ supplements.

8) Liver Function  
Normal NAD+ levels in the body are essential for the optimal functioning of the liver. Specific enzymes in the NAD+ pathways protect the liver from conditions such as hepatic fibrosis, nonalcoholic fatty liver disease, and nonalcoholic steatohepatitis.

9) Neurological Function  
NAD+ and its precursors have been shown to have a protective effect on the neurons in the brain after a significant neurological event such as a stroke. Having normal levels of NAD+ in the body is essential to the normal functioning and survival of cerebral neurons.

 

Benefits of IV NAD Therapy 
1) Addiction Therapy  
One of the most common reasons why IV NAD+ therapy may be considered in some individuals is in the management of addiction. IV NAD+ may benefit patients weaning off opioid, alcohol, chemical, or prescription drug dependencies; it may also serve to minimize the severity of withdrawal symptoms. While the mechanism of how NAD+ works in this regard is still under investigation, it is believed that IV NAD+ helps flush drugs out of the body and reduce cravings.

2) Improved Cognition  
NAD+ has been shown to exert both protective and stimulatory effects on the brain. For this reason, IV NAD+ therapy may be administered to potentially enhance memory, improve concentration, improve the ability to focus, enhance brain regeneration, and improve overall neurological function.

3) Chronic Fatigue  
IV NAD+ therapy has been used in the management of individuals with chronic fatigue and low energy levels. NAD+ is an essential cofactor in the glycolytic pathway and tricarboxylic acid pathways; these pathways result in Adenosine Triphosphate (ATP) production, which is the energy source of the human body.
4) Athletic Performance  
Due to its role in ATP production, some athletes have used IV NAD+ therapy to enhance their athletic capabilities and performance. IV NAD+ therapy may boost energy levels, improve cognition, and increase reaction times in athletes during competitions or other athletic events. In addition, studies have shown that NAD+ supplementation may assist in muscle development as well as muscle repair, leading to muscle hypertrophy and muscle hyperplasia.  
5) Pain Management  
One of the more novel reasons why some individuals receive IV NAD+ therapy is in managing pain. NAD+ is known to exert significant anti-inflammatory actions within body and may be used to reduce the inflammation that typically occurs with pain and, thereby, offer some relief from pain.
6) support weight loss                                                                                                                                                     NAD IV therapy increases energy levels, fights fatigue, and boosts your metabolism, which suggests that it can support weight loss.                                                                                                                                               7) Anti-Aging Effects
NAD+ has been shown to have powerful anti-aging effects, both at the cellular and systemic levels. By promoting DNA repair and reducing inflammation, NAD+ can help to slow down the aging process and reduce the risk of age-related diseases.
8) Improved Immune Function
NAD+ has also been shown to enhance immune function by promoting the production and activity of immune cells. This can help improve overall health and reduce the risk of infections and other illnesses. The body's metabolic processes are also improved, leading to better overall health.
 

Who Is NAD+ Therapy Right For?
   - Cardiovascular health
   - Memory problems
   - Alzheimer’s, MS, Parkinson’s
   - Cellular damage (mitochondrial diseases)
   - Chronic fatigue syndrome
   - Diabetes
   - Mental health (i.e. Anxiety, Depression, Chronic Stress)
   - Withdrawal symptoms from substance abuse
   - Anti-aging